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Contract Manufacturing

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Glucosamine Hydrochloride

One complementary medication that has been investigated for the treatment of OA is glucosamine. Glucosamine is a derivative of cellular glucose metabolism. It is also a component of glycosaminoglycans and proteoglycans of the cartilage matrix covering the ends of bones and hyaluronic acid which is a part of synovial fluid within the joint. The primary source of exogenous glucosamine is the exoskeleton of shellfish and exists in primarily two formulations, glucosamine hydrochloride (HCl) and glucosamine sulfate. Glucosamine sulfate requires compound stabilizers in the form of salts and has 74% purity. Glucosamine HCl lacks the sulfate group and has 99% purity. Therefore, glucosamine HCl in a dosage of 1,500 mg equals a dosage of 2,608 mg of glucosamine sulfate. Glucosamine is readily absorbed from the gastrointestinal tract with oral administration, rapidly undergoes metabolism via the liver and the first pass effect, and is eliminated through the feces and urine. Peak levels are in about 8 hours after oral ingestion primarily due to about 90% protein binding.

Chemical Structure
glucosamine-chemical

The mechanism of action of glucosamine in humans is unknown. Because glucosamine is a part of the cartilage matrix in joint tissues, it has been theorized for many years that its administration could affect symptomatic relief for OA sufferers by supplying the components for cartilage repair and thus improve pain and disability. More recently, however, it has been demonstrated in animal models that glucosamine has an anti-inflammatory effect via the reduction of nuclear factor kappa beta induced by interleukin-1 (IL-1). A few studies in humans have revealed that glucosamine HCl reduces IL-1 stimulated production of catabolic enzymes and inflammatory markers such as prostaglandin E2 by chondrocyte and synovial cells harvested from surgical specimens removed from patients with OA.

Chondroitin Sulphate

Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid).

Chondroitin sulfate is an important structural component of cartilage and provides much of its resistance to compression. Along with glucosamine, chondroitin sulfate has become a widely used dietary supplement for treatment of osteoarthritis.

Chemical Structure
chondroitin-sulphate-chemical

Chondroitin sulfate plays a central role in various biological processes, such as the function and elasticity of the articular cartilage, inflammation, cell adhesion, proliferation and differentiation. Number of commercial applications increased, due to its high biocompatibility, mainly in the engineering of biological tissues associated with the processes of bone repair, cartilage and cutaneous wound.

Andrographolide 95%

CAS number: 5508-58-7

Plant source: Andrographis paniculata

Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. Andrographolide is an extremely bitter substance extracted from the leaves of A. paniculata.

Andrographolide is used experimentally in different areas of research including cell signaling, immunomodulation, and stroke.

Colchicine 98%

CAS number: 64-86-8

Plant source: Colchicum autumnale

Colchicine is a medication most commonly used to treat gout. It is extracted from plants of the genus Colchicum (autumn crocus, Colchicum autumnale, also known as “meadow saffron”).

Colchicine is an alternative for those unable to tolerate NSAIDs in gout

Forskolin 95% and 97%

CAS number: 66428-89-5

Plant source: Coleus forskohlii

Forskolin (also called Coleonol) is a labdane diterpene that is produced by the Indian Coleus plant (Coleus forskohlii). Forskolin is commonly used to raise levels of cyclic AMP (cAMP) in the study and research of cell physiology. Forskolin activates the enzyme adenylyl cyclase and increases intracellular levels of cAMP.

Forskolin is also used in cosmetic formulations.

Glabridin 95%

CAS number: 59870-68-7

Plant source: Glycyrrhiza glabra

Glabridin (is a chemical compound that is found in the root extract of licorice (Glycyrrhiza glabra). Glabridin is an isoflavane, a type of isoflavonoid. This product is part of a larger family of plant-derived molecules, the natural phenols.

It is used as an ingredient in cosmetics and is listed in International Nomenclature of Cosmetic Ingredients (INCI).

Sesamin 90%, 95%

CAS number: 607-80-7

Plant source: Sesamum indicum

Sesamin is a lignan isolated from the sesame oil. It has been used as a dietary fat-reduction supplement, Sesamin and sesamolin are minor components of sesame oil, on average comprising only 0.14% of the oil by mass

WWithaferin – A 95%

CAS number : 5119-48-2

Plant source : Withania somnifera

Withaferin A is a steroidal lactone isolated from Winter cherry (Withania somnifera) and is the first member of the withanolides to be discovered. Withaferin A is a potent inhibitor of angiogenesis (the formation of new blood vessels). Withaferin A inhibits both NF-κB and Sp1 Transcription factor activity. Withaferin A also down regulates VEGF gene expression and can affect calcium signaling.

Triphala Extract

Botanical name: Terminalia chebula, Terminalia bellerica, Emblica officinalis

Triphala is a combination of three very powerful fruits that are known to possess intensive health benefits. Triphala is widely used in Ayurveda medicine and the three fruits that comprise it are Amla, Myrobalan, and Belleric Myrobalan.

Triphala has many benefits and it includes protection and enhancement of the functions of the body organs such as the eyes, skin, and heart. It can also cleanse the body so that energy is channeled better and more intensively. In its most natural form, triphala is known as the most effective combination of herbs that can cleanse the colon, keep the liver healthy, and flush out body toxins. It effectively regulates the functions of the digestive system, while enhancing the strength of the immune system, lungs, urinary tract, and the muscles.

Turmeric

Botanical name: Curcuma longa

Family: Zingiberaceae

Common Name: Turmeric

Part used:  Rhizome

Phytochemicals: Curcuminoids, Turmerones

Chemical Structure Specifications

Ar – Turmerone

turmeric-chemical

  • 95% total curcuminoids Powder, Granules
  • 85% curcuminoids : Ethanol grade
  • Water dispersible curcuminods

 

Lutein (Marigold)

Botanical name:  Tagetes erecta

Family:   Asteraceae

Common Name: Marigold

Part used:   Flower petals

Phytochemicals: Lutein and Zeaxanthin

Chemical Structure
lutein-chemical
Specifications
  • Lutein ester 5%,10%,20%powder/oil
  • Lutein ester40% Powder
  • Lutein free 5%,10%,20% powder/oil
  • Lutein free 75% Crystals
  • Lutein beadlets 10%,20%
  • Lutein water dispersible 5%,10%,20%

Category: Eye Health

Sesame

Botanical name: Sesamum indicum

Family: Pedaliaceae

Common Name: Sesame

Part used:  Seed

Phytochemicals: Sesamin, Sesamolin

Chemical Structure
sesame-chemical
Specifications
70% Sesamin complex, 95% Sesamin

Category: Cholesterol Management, Blood Sugar Support,  Weight Management

Salacia

Salacia Extract

Botanical name:  Salacia reticulata

Family: Hippocrateacaea

Common Name:  Salacia, Kotalahimbatu, Saptarangi

Part used:   Root and stem bark

Phytochemicals: Tannins and Triterpenes

Specifications
  • 2.5% triterpenes and 7% tannins

Category: Blood Sugar Support, Weight Management

Gymnema

Botanical name: Gymnema sylvestrae

Family: Asclepiadaceae

Common Name:  Gymnema, Madhunashini

Part used: Leaves

Phytochemicals: Gymnemic acids and Gymnemagenin

Chemical Structure
gymneya-chemical
Specifications
  • 25%,75% total gymnemic acid

Category: Blood Sugar Management